The system biology research was conducted in collaboration with a research team led by Professor Chu Kwang-hyun of KAIST’s Department of Bioengineering and Brain Engineering.
The results of the research were published in the online edition of the world-famous scientific journal, PNAS, on November 23 with an article titled “Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can reverse cellular aging of human cutaneous fibroblasts”).
As skin cells age, their ability to divide is significantly impaired, which slows down the speed of regeneration and the general function of skin tissue.
It also loses the ability to produce collagen and elastic fibers, which in turn slow down the regeneration of the skin making the skin thinner, thus creating wrinkles. In addition, the weakening of the skin barrier leads to frequent dryness, itchy skin, and other problems.
In this research collaboration between industry and the university, Amorepacific R&D and Professor Cho’s team developed a signaling network model for aging skin cells. The joint team ran simulations to analyze the model and discovered a core core that reverses aging in old cells and turns them into younger cells. Using this factor, the team was able to develop an original technology to reverse aging.